Logan is the Leader
Professor X is in a coma, Jean Grey is missing, and the X-Men are no more. But when Professor X contacts Wolverine from 20 years in the future, he reveals that The Sentinels have taken over all life on Earth, and that the planet has become a barren waste land. The only hope -- reassemble the X-Men and make Logan the leader. Now, with a team that doesn't know whether or not they can trust him, Wolverine must bring the old team back together in order to stop the future from coming to pass.
This series was an amalgamation of the comics universe and the movie universe. You can tell from the characters, designs, and locations that the movies were a big influence, but it takes the origins and characters from their original source material. This combination lets newcomers align themselves with whichever medium they're used to seeing the most popular mutants in.
The mutants themselves have a pretty big cast. There's alot of cameos from characters that don't normally show up in X-Men stories nowadays. I really enjoyed the major additions of Magneto's children into the story. Quicksilver and The Scarlet Witch play large roles in the movement of the story, and it was interesting to see them battle each other emotionally and physically when it comes to the future of the mutant race.
Wolverine's character is set to grow as a leader, and the transformation from loner to hero is fairly well done. There are episodes that stray from the main story, but they don't take away from the overall plot. It also does well to setup a second season and a much more threatening villain.
Overall I'd say it was a great X-Men cartoon. The animation wasn't bad, but it was pretty standard. The voice acting was superb however, and there were no times when I thought it was over the top or goofy.
Pick it up and watch it if you want to see a mix of past X-Men lore in a contemporary setting.